6-Chloro Nicotinaldehyde
6-Chloro Nicotinaldehyde
CAS: 23100-12-1
Molecular Formula: C6H4ClNO
6-Chloro Nicotinaldehyde - Names and Identifiers
6-Chloro Nicotinaldehyde - Physico-chemical Properties
| Molecular Formula | C6H4ClNO |
| Molar Mass | 141.56 |
| Density | 1.332±0.06 g/cm3(Predicted) |
| Melting Point | 77-81°C(lit.) |
| Boling Point | 117-119 °C(Press: 5 Torr) |
| Flash Point | 104.576°C |
| Water Solubility | Soluble in water. |
| Vapor Presure | 0.023mmHg at 25°C |
| Appearance | White-like crystal |
| Color | White to yellow |
| pKa | -1.85±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.593 |
| MDL | MFCD03095223 |
6-Chloro Nicotinaldehyde - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
6-Chloro Nicotinaldehyde - Reference Information
| introduction | 6-chloronicotine is a white or yellow-white solid powder under normal temperature and pressure, which can be used as an intermediate in organic synthesis. 6-Chloronicotinaldehyde is a commercial organic synthon. It has good solubility in common organic solvents such as dichloromethane, chloroform, dimethyl sulfoxide, and ethyl acetate, and it also has a certain degree in water. Solubility. |
| Use | 6-chloronicotinic aldehyde is a common organic synthesis intermediate. The aldehyde group on the pyridine ring can be easily converted into a series of Active functional groups, such as hydroxyl, double bond, triple bond, carboxyl group, etc. In addition, the chlorine atoms on the pyridine ring can be coupled by Suzuki, introducing aryl groups, alkyl groups, etc. on the pyridine ring. |
| Synthesis method | For the synthesis of 6-chloronicotinic aldehyde, the conventional synthesis method starts from its corresponding 2-chloro-5-hydroxymethylpyridine and oxidizes the hydroxyl group to an aldehyde group through swern oxidation; it is worth noting that the oxidation reaction of this substrate must use swern oxidation to be successful, and it is oxidized with conventional PCC, or the oxidation reaction effect of Desmartin is not good, it is probably because of the pyridine ring, because pyridine itself is also easily oxidized by the oxidant. |
| environmental hazards | 6-chloronicotine, as a halogen-containing heterocyclic aromatic hydrocarbon compound, is more harmful to the water environment and cannot allow undiluted or large amounts of products to contact groundwater, waterways or sewage systems. |
Last Update：2024-04-09 15:16:49
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